Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif.
نویسندگان
چکیده
A branching DOS strategy for an unbiased natural product-like library with embedded privileged benzopyran motif was established to provide complexity and diversity of resulting heterocycles with desired drug-likeness. The importance of skeletal diversity conducted on a privileged substructure was demonstrated through the biological evaluation of a small molecule library representing 22 unique core skeletons via in vitro cytotoxicity assay.
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عنوان ژورنال:
- Chemical communications
دوره 28 شماره
صفحات -
تاریخ انتشار 2006