Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif.

نویسندگان

  • Sung Kon Ko
  • Hwan Jong Jang
  • Eunha Kim
  • Seung Bum Park
چکیده

A branching DOS strategy for an unbiased natural product-like library with embedded privileged benzopyran motif was established to provide complexity and diversity of resulting heterocycles with desired drug-likeness. The importance of skeletal diversity conducted on a privileged substructure was demonstrated through the biological evaluation of a small molecule library representing 22 unique core skeletons via in vitro cytotoxicity assay.

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عنوان ژورنال:
  • Chemical communications

دوره 28  شماره 

صفحات  -

تاریخ انتشار 2006